Immunomodulating polyphenols from Sideritis scardica

The herb Sideritis scardica is used in traditional medicine the Balkan Peninsula. Limited information exists on its health effects, such as improvement of cognitive functions. This study explores vitro anti-inflammatory effects extracts and polyphenols S. with focus neurodegenerative disease. BuOH, DCM EtOAc fractions were isolated from crude EtOH extract aerial parts further purified by chromatographic methods. Eleven phenolic compounds isolated. assessed for immunomodulatory, enzyme-interacting cytotoxic properties. extract, fraction precipitate, BuOH fraction, verbascoside acetylallosylglucosyl-isoscutellarein 4?-methylether displayed DPPH scavenging activity. echinaticin XO inhibiting reduced nitric oxide production D2SC/1 dendritic cells demonstrated potent activity a human complement assay. Verbascoside chlorogenic acid lowered NO levels without affecting cell viability cells. results reveal broad-spectrum this herb, which might potentially serve multi-target system Alzheimer’s